Working Principle of Stability Chamber

Stability chambers work on the idea of using thermostats and water in the chamber to maintain the relative humidity (RH) and temperature of the chamber. According to physics, high temperatures in the chamber assist the air keep higher humidity since high temperatures improve the capability of air to maintain higher humidity under specified conditions, which is how the stability chamber works.

Stability chambers are used to provide artificially recreated environments for medicines that may be exposed to a wide range of conditions. It’s occasionally utilized to speed up the effects of being exposed to possibly harmful air conditions at any location where this medicine is kept.

The stability of a product manufactured in the United States may not be sustainable in Indian environmental conditions, so it is critical to test it in Indian environmental conditions developed in a stability chamber in a US laboratory. By accelerating the settings, the maker can analyze the effects of the stability chamber’s circumstance on the product in a short amount of time.

Stability Chamber Standard Operating Procedures.

1. Objectives

To establish a technique for operating a Stability Chamber Manufacturers with complete PLC control and a touch screen HMI [LABO].

2. Scope                                  

This method applies to the XYZ Pharma company’s Quality Control Department.

Executive/Quality Control Officer

Manager of quality assurance.

3. Procedure.

• To begin the stability chamber, turn on the mains switch on the control panel.
• The Set Point and process value of the controlling sensor is displayed at the top of the main screen.
• The auto-tuning state for temperature and humidity is shown by an AT to the right of the setpoint window.
• REFRIG. SYS displays the status of the refrigeration system.
• The value humid. SYS denotes which humidity system is active.
• Chamber displays the current state of the chamber along with a countdown timer. OFF mode, running mode, and stabilization, for example.
• Main or standby temp. Sensor specifies which temperature sensor is in control.
• Humid sensor shows if the main or standby humidity sensor is in control.
• The active alarm status is shown just below the sensor status strip. If the strip is red, the alarm is turned on. If the strip is yellow, the alarm has been accepted.
• When the start button on the PLC is hit, the system will only turn on the primary contractor. After 2 minutes, the blower and refrigeration system should turn on. After the blower and refrigeration systems have started, the air heater and healthy humidity system will start with PID action after a 30-second delay.

Use HMI to set the temperature

• To change the temperature, go to the main page and select Menu from the drop-down Menu.
• Select the TEMP. CONT. A button from the Main Menu Page, which will lead you to the page shown below.
• The temperature regulating sensor and temperature scanners have parameters that can be changed on this page.
• Users can also start the temperature auto-tuning on this page by pressing the button on the top-right side of the screen.
• After you’ve made the necessary adjustments, use the HMI’s save button to preserve the changes you’ve made.

Change the Humidity to HMI

• From the Main Menu Page, select HUMID. CONT., which will take you to the page shown below.
• The parameters for the humidity regulating sensor and humidity scanners can be set on this page.
• Users can also start the temperature auto-tuning on this page by pressing the button on the top-right side of the screen.
• After you’ve made the necessary adjustments, use the HMI’s save button to preserve the changes you’ve made.

Check the reading on the scanner

• A scanner with eight channels is built into the PLC, with four sensors for temperature mapping and four sensors for humidity kept at different locations and a printer and PC interface through the HMI. The scanned information can be imported into the Stability Control System software and printed on a dot-matrix printer.
• The scanner readings can be viewed by clicking the VIEW button on the main page, which will take you to the page displayed below.
• TEMP 1 TO TEMP 4: Shows the current process value of the temperature sensors on channels 1 to 4. Out of range from the top limit is indicated by a value with a red backdrop. Out of range from the Lower limit is indicated by a value with a blue backdrop.
• HUMI 1 to HUMI 4: Shows the current process value of the humidity sensors on channels 1 to 4.
• Out of range from the top limit is indicated by a value with a red backdrop. Out of range from the Lower limit is indicated by a value with a blue backdrop.

How do stability chambers work?

According to the law of physics, the greater the chamber’s temperature, the better the air’s ability to retain moisture at that temperature. The amount of moisture in the air to the amount of moisture that the air has the potential to hold is known as relative humidity. In layman’s terms, this indicates that changes in ambient temperature can impact relative humidity.

As a result, the operation of a stability chamber is dependent on its ability to maintain a constant temperature and, as a result, a constant relative humidity value. These rooms can be used to keep biological samples and cytological specimens. They can also be used to determine how quickly medically active chemicals accelerate and decelerate.

Applications and features.

Drug and medical firms are the most common users of stability chambers. They can also be employed in hospitals and research institutes. They are mostly used to test large-scale tools and production samples where temperature and humidity must be monitored and controlled. A team of qualified professionals designs the stability chambers to satisfy the needs of the clients.

Advantages of stability chambers

Manufacturers of stability chambers in India provide the device with several unique features that enable the chamber to maintain a low temperature. A researcher can use the chamber to keep anything cool. Plants, live cells, and pharmaceuticals are all subjected to temperature testing. These studies are carried out to determine whether a material can withstand a specific temperature.

The stability chamber is simple to use and may even be operated by a novice. They provide a consistent temperature throughout the chamber, so the temperature will be maintained no matter what you put in it.

Conclusion

The concept of operation for all industries’ stability chambers is the same. Environmental chambers are utilized in every industry to test product stability in intentionally worsened conditions by accelerating temperature and relative humidity.